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不同的药物可引起不同类型的肝损害,根据组织学改变,急性肝损害又可分为肝细胞中毒型(亦称肝炎型),胆汁郁滞型(亦称过敏型)和混合型三种。肝炎型药物性肝损害的发病特点有:1.肝损害程度与药物剂量密切相关;2.发病率比胆郁型多见;3.肝损害在动物中重复性高,临床上可见相仿表现;4.用药后发病时间与药物剂量、方法及机体情况有密切关系。过敏型药物性肝损害的特点有:1.发病率低;2.发病与用药剂量关系不大;3.用药后到发生肝损害的时间短;4.动物实验缺乏复制性;5.常伴有各种过敏表现如发热、皮疹、关节炎、酸性白细胞增多等,肝活检在毛细胆管附近有酸性细胞浸润;6.停药后上述各种表现迅速消散,预后良好。引起药源性黄疸的药物
Different drugs can cause different types of liver damage, according to histological changes, acute liver damage can be divided into hepatotoxicity (also known as hepatitis type), cholestasis type (also known as allergic type) and mixed type three. The incidence of hepatitis-induced drug-induced liver injury are: 1. The degree of liver damage is closely related to the dose of the drug; 2. The incidence is more common than the type of biliary depression; 3. The liver damage is highly reproducible in animals and can be seen clinically; 4. After the onset of medication and drug dosage, methods and the body is closely related to the situation. Allergic drug-induced liver damage is characterized by: 1. The incidence is low; 2. The incidence and dosage is not related; 3. After treatment, the time to liver damage is short; 4. The lack of reproductive animal experiments; There are a variety of allergic manifestations such as fever, rash, arthritis, leukocytosis, etc., liver biopsy in the vicinity of capillary bile duct acid cell infiltration; 6. After discontinuation of the various performance quickly dissipated, the prognosis is good. Drugs that cause jaundice