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目的 :通过对增殖性糖尿病视网膜病变 (proliferative diabetic retinopathy,PDR)患者玻璃体中转化生长因子 β2(TGF-β2 )含量的研究 ,探讨 TGF-β2 在 PDR病理过程中的作用。 方法 :应用酶联免疫吸附测定法对 10例 (10只眼 )正常人及2 4例 (2 4只眼 ) PDR患者玻璃体中 TGF- β2 的含量进行检测和分析。 结果 :10例正常人玻璃体中 ,TGF- β2 的含量为 (1.2 7±0 .6 9) ng/ml;2 4例 PDR患者玻璃体中 ,TGF- β2 的含量为 (4 .89± 3.5 1) ng/ml。两组比较 ,PDR组的玻璃体中 TGF- β2 的含量明显升高 ,差异非常显著 (P<0 .0 1)。将糖尿病视网膜病 期及 期 14例 (14只眼 )患者列为一组 ,10例 (10只眼 ) 期患者另列一组 ,玻璃体中 TGF- β2 的含量分别为 (6 .0 7± 4.0 5 )及 (2 .84± 1.72 ) ng/m l,两组间比较有显著差异 (P<0 .0 5 )。它们分别与正常对照组比较也有非常显著差异 (P<0 .0 1)和显著差异 (P<0 .0 5 )。结论 :PDR患者玻璃体中 TGF- β2 的含量升高 ,提示 TGF- β2 在 PDR的病理发展过程中可能起重要作用
Objective: To investigate the role of TGF-β2 in the pathogenesis of PDR by studying the content of transforming growth factor-β2 (TGF-β2) in the vitreous of proliferative diabetic retinopathy (PDR). Methods: The content of TGF-β2 in the vitreous body of 10 PD patients (10 eyes) and 24 PDR patients (24 eyes) were detected by enzyme linked immunosorbent assay (ELISA). Results: The content of TGF-β2 in the vitreous of 10 normal subjects was (1.2 7 ± 0. 6.9) ng / ml. In the vitreous of 24 patients with PDR, the content of TGF-β2 was (4.89 ± 3.51) ng / ml. In the two groups, the content of TGF-β2 in the vitreous of PDR group was significantly increased, the difference was significant (P <0.01). A total of 14 patients (14 eyes) with stage and stage diabetic retinopathy were enrolled. One of the 10 patients (10 eyes) had another group. The content of TGF-β2 in the vitreous was (6.07 ± 4.0) 5) and (2.84 ± 1.72) ng / ml respectively. There was significant difference between the two groups (P <0.05). They were also significantly different from the normal control group (P <0.01) and significant difference (P <0.05). Conclusion: The increase of TGF-β2 in the vitreous of PDR patients suggests that TGF-β2 may play an important role in the pathological development of PDR