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目的:建立依地酸二钠(EDTA-2Na)中残留甲醛的测定方法.方法:采用顶空气相色谱法测定.Agilent DB-WAX气相毛细管柱(30 m×0.32 mm,0.5 μm),分流进样,分流比为2: 1;载气为N2,流速为1.0 ml·min-1;检测器为FID;进样口温度为230℃,检测器温度为260℃;采用程序升温法:起始温度40℃,保持6 min,再以40℃·min-1速率升温到230℃后,维持10 min;进样量为1 μl.分别取对照品溶液和供试品溶液,95℃加热平衡25 min,顶空进样,按外标法以峰面积计算含量.结果:甲醛标准溶液在5.10~102.00 μg·ml-1浓度范围内与峰面积的线性关系良好(r=0.9997),平均回收率为84.60%(RSD=3.82%,n=9).结论:本方法简单、快速、准确,可以用于依地酸二钠中甲醛残留量的测定.“,”Objective:To establish a headspace GC method for the determination of residual formaldehyde in EDTA-2Na. Meth-ods:A headspace GC was used to separate the residual solvents on an Agilent DB-WAX (30 m×0.32 mm,0.5 μm) capillary col-umn with an FID detector. The carrier gas was nitrogen at the flow rate of 1.0 ml·min-1. The temperature of the injector was 230 ℃and that of the FID was 260 ℃. The programmed column temperature was set as follows: maintained at 40 ℃ for 6 min, and then raised to 230 ℃ at the rate of 40 ℃·min-1and maintained for 10 min. The injection volume was 1μl with the split ratio of 2:1. The reference solvent and sample were filled into the containers of headspace injector and the containers were in equilibrium at 95℃ for 25 min. The amount of residual formaldehyde was calculated by an external standard method.Results:There was a good linear relationship of formaldehyde reference solvent within the concentration range of 5.10-102.00 μg·ml-1(r=0.999 7). The average recovery was 84.60%(RSD=3.82%,n=9). Conclusion: The method is simple,rapid and accurate for the determination of residual formalde-hyde in EDTA-2Na.