论文部分内容阅读
目的:检测抗环瓜氨酸肽(CCP)抗体在类风湿性关节炎(RA)中的阳性率,探讨抗CCP抗体检测在RA中的意义。方法:用ELISA方法检测30例RA,35例其他风湿性疾病,20例非风湿性疾病中的抗CCP抗体的分布。用免疫比浊法测定类风湿因子(RF),比较抗CCP抗体与RF的相关性。结果:30例RA病人中,抗CCP抗体的阳性率为73.33%。抗CCP抗体对RA的敏感性和特异性分别为73.33%和94.54%。RF的阳性率为76.67%。RF抗体对RA的敏感性和特异性分别为76.67%和80.0%。抗CCP抗体与RF之间呈正相关性。结论:抗CCP抗体对RA具有良好的敏感性和特异性,可视为RA新的血清学诊断指标,能用于RA的诊断。同时联合检测抗CCP抗体和RF有助于提高RA检测的敏感性和特异性。
Objective: To detect the positive rate of anti-cyclic citrullinated peptide (CCP) antibody in rheumatoid arthritis (RA) and to explore the significance of detecting anti-CCP antibody in RA. Methods: The distribution of anti-CCP antibodies in 30 patients with RA, 35 other rheumatic diseases and 20 non-rheumatic diseases was detected by ELISA. Rheumatoid factor (RF) was measured by immunoturbidimetry and the correlation between anti-CCP antibody and RF was compared. Results: Among 30 RA patients, the positive rate of anti-CCP antibody was 73.33%. The sensitivity and specificity of anti-CCP antibodies to RA were 73.33% and 94.54%, respectively. The positive rate of RF was 76.67%. The sensitivity and specificity of RF antibodies to RA were 76.67% and 80.0%, respectively. There was a positive correlation between anti-CCP antibody and RF. CONCLUSION: Anti-CCP antibodies have good sensitivity and specificity for RA and may be regarded as a new serological diagnostic index for RA and can be used for the diagnosis of RA. Simultaneous detection of anti-CCP antibodies and RFs can improve the sensitivity and specificity of RA assays.