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虽然2型糖尿病肥胖患者存在胰岛素抵抗,但是胰岛β细胞功能衰竭才是糖尿病发生发展的核心机制。胰岛β细胞功能衰竭在出现高血糖之前就发生了。虽然临床试验数据显示,强化生活方式干预能够延缓肥胖者糖尿病的发生,但是其内在的机制并不清楚;例如,减肥手术(尤其是胃旁路手术)对糖尿病的作用机制。因此,本文就生活方式干预和胃旁路手术对胰岛β细胞功能的作用进行了评估,以及就肠促胰岛素恢复β细胞功能的相关机制进行了探讨。
Although insulin resistance exists in patients with type 2 diabetes and obesity, pancreatic β-cell failure is the core mechanism of the development of diabetes. Pancreatic beta-cell failure occurs before hyperglycemia occurs. Although clinical trial data show that intensive lifestyle interventions can delay the onset of diabetes in obese individuals, the underlying mechanisms are not clear; for example, the mechanism of action of bariatric surgery, especially gastric bypass surgery, on diabetes. Therefore, we evaluated the effects of lifestyle interventions and gastric bypass surgery on pancreatic β-cell function, as well as the mechanisms involved in the role of incretin in the recovery of β-cell function.