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目的初步探讨上海市学龄儿童双酚A的暴露现状及其与肥胖的关系。方法收集500名6~11岁的在校小学生的尿样,采用高效液相色谱法检测其尿液总双酚A浓度,并进行体格测量和评估。结果被检儿童的尿液双酚A检出率为77.2%,浓度范围ND~79.52ng/mL,中位数1.32ng/mL,四分位数间距为0.35~4.01ng/mL。其中女生尿液双酚A浓度高于男生,差异有统计学意义(Z=-3.687,P<0.01);8~11岁组尿液双酚A浓度高于6~7岁组(Z=-1.986,P<0.05)。肥胖及超重率高达32.9%,其中肥胖率为12.9%,超重率为20.1%,消瘦率为2.6%,男童肥胖率高于女童,差异有统计学意义(χ2=24.935,P<0.01)。肥胖组、超重组、消瘦组与正常体重组之间尿液双酚A浓度差异均无统计学意义(P>0.05)。结论上海市学龄儿童普遍存在双酚A暴露;学龄儿童存在严重的肥胖问题。
Objective To investigate the status of bisphenol A exposure in school-age children in Shanghai and its relationship with obesity. Methods Urine samples of 500 primary schoolchildren aged 6-11 years were collected. The total urinary BPA concentration was measured by high performance liquid chromatography (HPLC), and physical measurements and assessment were performed. Results The detection rate of urine bisphenol A in children was 77.2%. The range of ND was 79.52ng / mL, the median was 1.32ng / mL, and the interquartile range was 0.35 ~ 4.01ng / mL. The urine concentration of bisphenol A was higher in girls than in boys (Z = -3.687, P <0.01). The urine bisphenol A concentration in girls aged 8 to 11 was higher than that in 6-7 years old group (Z = 1.986, P <0.05). Obesity and overweight rates were as high as 32.9%. Obesity rate was 12.9%, overweight rate was 20.1%, wasting rate was 2.6%, and obesity rate was higher in boys than in girls (χ2 = 24.935, P <0.01). There was no significant difference in urinary bisphenol A concentration between obesity group, overweight group, weight loss group and normal weight group (P> 0.05). Conclusion The prevalence of bisphenol A exposure exists in school-age children in Shanghai. There is a serious obesity problem in school-age children.