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目的:探讨不同强度运动和雌激素联合作用对去卵巢大鼠骨骼生物力学性能的影响。方法:将80只成年雌性SD大鼠按体重随机分为基础对照组、假手术组、骨质疏松对照组、雌激素对照组、低强度运动组、低强度运动加雌激素组、中等强度运动组、中等强度运动加雌激素组、大强度运动组以及大强度运动加雌激素组,利用858BIONIX生物力学检测系统测定8周实验后各组大鼠股骨颈最大载荷、第2腰椎最大凹入载荷和第3腰椎最大压缩载荷。结果:(1)与假手术组比,骨质疏松对照组的股骨颈最大载荷、第2腰椎最大凹入载荷和第3腰椎最大压缩载荷3项力学性能指标分别降低了50%、40%和27%(P<0·05)。(2)与骨质疏松对照组和雌激素对照组比,大鼠去卵巢后3种强度的单纯运动组和运动加雌激素联合组股骨颈最大载荷均显著增加(P<0·05),且随运动强度的增加而增加(P<0·05);相同强度下,运动加雌激素联合组的股骨颈最大载荷与单纯运动组无显著性差异。(3)单纯大强度运动组的第2腰椎最大凹入载荷和第3腰椎最大压缩载荷较骨质疏松对照组和雌激素对照组显著增加(P<0·05);低强度运动加雌激素组第2腰椎最大凹入载荷和第3腰椎最大压缩载荷两项力学指标既显著高于单纯低强度运动组(P<0·05),也显著高于雌激素对照组(P<0·05)。中等强度运动加雌激素组的第2腰椎最大凹入载荷显著高于单纯中等强度运动组(P<0·05)及雌激素对照组(P<0·05)。结论:单纯运动对力直接作用部位的力学性能———股骨颈最大载荷的影响大于单纯补充雌激素,运动和雌激素无明显协同作用;对于非力直接作用部位的力学性能———第2腰椎最大凹入载荷及第3腰椎最大压缩载荷,运动和雌激素联合有一定的协同作用。
Objective: To investigate the effects of different intensity exercise and estrogen on the biomechanical properties of skeletal bone in ovariectomized rats. Methods: Eighty adult female SD rats were randomly divided into basic control group, sham operation group, osteoporosis control group, estrogen control group, low-intensity exercise group, low-intensity exercise plus estrogen group, moderate-intensity exercise group Group, moderate-intensity exercise plus estrogen group, high-intensity exercise group and high-intensity exercise plus estrogen group. The maximum load of femoral neck and the maximum concave load of the second lumbar vertebrae were measured by the 858BIONIX biomechanical test system after 8 weeks. And the 3rd lumbar vertebra maximum compressive load. Results: (1) Compared with the sham group, the mechanical properties of the osteoporosis control group decreased by 50%, 40% and 3% respectively under the maximum femoral neck load, the maximum concave load of the second lumbar vertebra and the maximum compressive load of the third lumbar vertebrae 27% (P <0.05). (2) Compared with osteoporosis control group and estrogen control group, the maximal load of femoral neck of 3 kinds of intensity exercise group and exercise plus estrogen combination group significantly increased after ovariectomized (P <0.05) And increased with the increase of exercise intensity (P <0.05). Under the same intensity, the maximal femoral neck load of exercise plus estrogen combination group had no significant difference with that of simple exercise group. (3) Compared with osteoporosis control group and estrogen control group, the maximal concave load of 2nd lumbar vertebra and the 3rd lumbar vertebral maximum compressive load of pure high-intensity exercise group were significantly increased (P <0.05); low-intensity exercise plus estrogen The maximal mechanical load of the 2nd lumbar vertebrae and the 3rd lumbar vertebra of the 2nd lumbar vertebra were significantly higher than those of the low-intensity exercise group (P <0.05) and the estrogen control group (P <0.05) ). The maximal concave load of the 2nd lumbar vertebrae of the moderate-intensity exercise plus estrogen group was significantly higher than that of the middle-intensity exercise group (P <0.05) and the estrogen control group (P <0.05). CONCLUSION: The mechanical properties of the direct action site of simple motion --- the influence of the maximal load of the femoral neck is greater than that of pure estrogen, and there is no obvious synergistic effect between exercise and estrogen. For the mechanical properties of the direct action site of non-force --- the second lumbar vertebra Maximum concave load and the third lumbar maximum compressive load, exercise and estrogen combination have some synergy.