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目的:探讨沙利度胺联合化疗对慢粒加速期疗效。方法:先给予联合化疗,无效后在原方案基础上加用沙利度胺。结果:给予沙立度胺联合化疗3个疗程后临床及血液学获得缓解。结论:沙利度胺具有抑制血管增生和免疫调节作用,为恶性血液病的治疗提供新的途径。由于无骨髓抑制,故可与化疗药物联合应用提高疗效除便秘外未发现其他毒副反应。
Objective: To investigate the effect of thalidomide combined with chemotherapy on cochlear acceleration. Methods: The first combination chemotherapy, invalid after the original program based on the use of thalidomide. Results: The clinical and hematological remission were given after 3 courses of thalidomide combined with chemotherapy. Conclusion: Thalidomide can inhibit vascular proliferation and immune regulation and provide a new approach for the treatment of hematologic malignancies. Because of no myelosuppression, it can be used in combination with chemotherapy drugs to improve the efficacy of other than constipation found no other side effects.