现有的“老牌”抗心律失常药(包括奎尼丁、普鲁卡因胺、吡二丙胺、利多卡因、苯妥英钠、β阻滞剂、溴汴铵托西酸盐以及维拉帕米等),其抗心律失常疗效有限,不良反应较多,因而促进了抗心律失常新药的研究与发展。已发现的抗心律失常新药中,多数较之“老牌”药物效果更好,毒性更低。西苯唑啉(Cibenzoline,Ciprelan) 本品为咪唑衍生物,药效学特征类似奎尼丁,大致属于IA类抗心律失常药。可缩小动作电位振幅,降低动作电位上升速率,减慢传导速度和延长动作电位时程。对 Existing “veteran” antiarrhythmic drugs (including quinidine, procainamide, pyrilamine, lidocaine, phenytoin, beta blockers, brompheniramine hydrochloride and verapamil Etc.), its anti-arrhythmic effect is limited, more adverse reactions, thus promoting the anti-arrhythmic drug research and development. Among the new anti-arrhythmic drugs that have been found, most are more effective and less toxic than “veteran” medications. Cibenzoline (Cibenzoline, Ciprelan) This product is imidazole derivatives, pharmacodynamic characteristics similar to quinidine, roughly belongs to the class IA antiarrhythmic drugs. The amplitude of the action potential can be reduced, the rate of rise of the action potential can be reduced, the conduction velocity can be slowed and the action potential duration can be prolonged. Correct