论文部分内容阅读
苯并咪唑类药物可引起寄生虫微管系统的紊乱,导致虫体死亡。但在绵羊中广泛使用抗蠕虫药可产生抗药虫群;以往因缺乏敏感的方法而使对抗药性遗传机制的研究有很大困难。作者用绵羊捻转血矛线虫(Haemonchus contortus)和蛇形毛圆线虫(Trichostrongylus colubriformis)的苯并咪唑(BZ)敏感群体(BZ-S)和抗性群体(BZ-R)的β-微管蛋白基因进行限制性片段长度多态性分析(RFLP)以研究抗性产生的机制。生化
Benzimidazole drugs can cause parasite microtubule system disorders, resulting in death of parasites. However, widespread use of anti-worm drugs in sheep can produce resistant insects; in the past due to the lack of sensitive methods to make genetic research on drug resistance has great difficulties. The authors used the beta-microtubules of the sheep susceptible population (BZ-S) and the resistant population (BZ-R) of Haemonchus contortus and Trichostrongylus colubriformis Protein gene restriction fragment length polymorphism (RFLP) to study the mechanism of resistance. Biochemical