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目的 :探讨IgA肾病患者临床与病理类型间的关系 ,为临床治疗及判断预后提供依据。方法 :对 4 8例IgA肾病患者的临床特点、病理类型、免疫病理分级进行回顾性分析。结果 :IgA肾病中以血尿合并蛋白尿最多见 ,占 60 4 % ,临床类型与病理分级未发现有相关性 ,但病理分级高 ,提示肾损害严重 ,预后不良 ,免疫病理分级与病理类型无密切关系。重度蛋白尿组的血肌酐、血尿素氮显著高于轻、中度蛋白尿组。结论 :大量蛋白尿可能促进IgA肾病的肾功能损害进展
Objective: To investigate the relationship between clinical and pathological types of patients with IgA nephropathy and to provide evidence for clinical treatment and prognosis. Methods: The clinical features, pathological types and immunopathological grades of 48 patients with IgA nephropathy were retrospectively analyzed. Results: Hematuria and urinary proteinuria were the most common in IgA nephropathy, accounting for 60.4%. There was no correlation between clinical type and pathological grade, but high pathological grade, which indicated severe renal damage and poor prognosis. Immunopathological grading and pathological type were not closely related relationship. Serum creatinine and blood urea nitrogen in severe proteinuria group were significantly higher than those in mild and moderate proteinuria group. Conclusion: A large amount of proteinuria may promote the progression of renal dysfunction in IgA nephropathy