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本文用放免法检测５４例正常人（对照组），１６９例各型肝病患者血清中透明质酸（ＨＡ），其结果表明，肝硬化患者的ＨＡ值（９０９．５±２５０．９μｇ／Ｌ）为最高，与对照组（５４．６±２６．７９μｇ／Ｌ）相比较有显著差异（Ｐ＜０．００１）．ＣＰＨ１０４．６３±５９．２１μｇ／Ｌ，ＣＡＨ４５６．７±１２８．９μｇ／Ｌ，提示ＨＡ是一项ＣＰＨ与ＣＡＨ二者鉴别诊断生化指标，同时也是一项肝硬化诊断的标志，优于其它肝功项目。血清ＨＡ增高的机理有三点：１）肝严重受损时，肝间质细胞合成ＨＡ增高。２）肝病时免疫监视能力低下对ＨＡ的清除能力下降。３）肝受损时，内皮细胞数量减少其功能减退，分解代谢降低。
In this paper, 54 cases of normal control group (control group) and 169 cases of liver disease patients with hyaluronic acid (HA) were detected by radioimmunoassay. The results showed that the HA value of patients with cirrhosis (909.5 ± 250.9μg / L) Was the highest, compared with the control group (54.6 ± 26.79μg / L) compared to significant differences (P <0.001). CPH104.63 ± 59.21μg / L, CAH456.7 ± 128.9μg / L, suggesting that HA is a differential diagnosis of biochemical indicators of both CPH and CAH, but also a sign of cirrhosis diagnosis, superior to other liver function project. The mechanism of serum HA increased three points: 1) when the liver is severely damaged, the synthesis of HA increased liver interstitial cells. 2) Immunocompromised patients with liver disease have poor ability to remove HA. 3) When the liver is damaged, the number of endothelial cells is reduced and its function is diminished and catabolism is reduced.