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下丘脑多肽激素领域中的一项重要成就是生长抑制素的发现。最早 Krulich 等(1968)设想这一物质的存在。1972年 Brazeau 等在用羊下丘脑精制黄体生成素释放激素(LRH)的过程中,发现了一种能抑制生长激素分泌的多肽,经提纯和鉴定,确定其化学结构为一环状十四肽,命名为生长抑制素(somatostatin,以下简称 SS)。自 SS 被发现后的短短时间内,已证明它有广泛的生物学作用和解剖学分布,对所有试验过的哺乳动物都有作用,尤其是考虑到它在临床应用的前景,已引起人们的注意。现将有关 SS 的近年资料扼要介绍如下。
An important achievement in the field of hypothalamic polypeptide hormones is the discovery of somatostatin. The earliest Krulich et al. (1968) envisioned the existence of this material. In 1972, Brazeau et al. Used a sheep hypothalamus to purify luteinizing hormone-releasing hormone (LRH) and found a peptide that inhibits the secretion of growth hormone. After purified and identified, the chemical structure of the peptide was determined to be a cyclic tetrapeptide , Named somatostatin (hereinafter referred to as SS). It has been shown that SS has a wide range of biological and anatomic distributions within a short period of time since its discovery and has been implicated in all tested mammals, especially considering its potential for clinical application and has caused people Attention. Now SS related information in recent years are briefly described below.