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目的探讨军人乙肝疫苗免疫效果,查找无或低应答原因。方法利用某部干部年度体检资料,调查2000—2007年间乙肝疫苗免疫后抗-HBs阳转率统计分析免疫应答的影响因素。结果调查3830名干部在8年间从年度抗-HBs阳转率9.30%逐步提高为59.5%(P<0.01)。由基因重组(酵母)乙肝疫苗改用基因重组(CHO细胞)乙肝疫苗后,抗-HBs阳转率提高到72.96%,(P<0.01)。大年龄组抗-HBs阳转率低于小年龄组,机关干部低于旅(团)干部,吸烟和饮酒者低于不吸烟和不饮酒者,经统计学检验,均P<0.01。结论成人接种乙肝疫苗抗-HBs阳转率明显低于儿童,乙肝疫苗种类应首选基因重组(CHO细胞)疫苗。年龄及不良生活行为对抗-HBs阳转率有一定的影响。
Objective To investigate the effect of hepatitis B vaccine on soldiers and to find out the causes of no or low response. Methods The annual medical examination data of a certain cadre were used to investigate the influencing factors of anti-HBs positive rate of hepatitis B vaccine immunization after 2000-2007 immunization. Results 3830 cadres were surveyed and gradually increased to 59.5% (P <0.01) from the annual anti-HBs positive rate of 9.30% in 8 years. The anti-HBs positive rate increased to 72.96% (P <0.01) after the gene recombinant (yeast) hepatitis B vaccine was switched to gene recombinant (CHO cell) hepatitis B vaccine. The positive rate of anti-HBs in older age group was lower than that of the younger age group, the cadres in organs were lower than those in brigade (CYPC), and those who smoked and drank less than non-smoker and non-drinkers. All were statistically significant (P <0.01). Conclusion The positive rate of anti-HBs in hepatitis B vaccination in adults is obviously lower than that in children. The vaccine of hepatitis B vaccine should be the first choice of recombinant CHO vaccine. Age and adverse life behavior have a certain impact on anti-HBs positive conversion rate.