目的 :评价托百士 (0 .3%妥布霉素 )眼药的临床疗效。方法 :外眼感染患者随机分成托百士治疗组与氧氟沙星治疗组进行对照研究 ,于用药前、用药后 4～ 5天、 9～ 10天分别作细菌培养 ,根据临床观察 (症状和体征综合评分 )及菌培养结果判定药物的治疗效果。结果 :115例菌培养阳性的外眼感染患者 ,托百士组 75例 ,显效 36例 ,有效 34例 ,总有效 70例 ,有效率 93.33% ;氧氟沙星组 40例 ,显效 15例 ,有效 2 1例 ,总有效 36例 ,有效率 90 % ;二者统计学处理无显著差异。药敏试验妥布霉素敏感率为 93.97% ,氧氟沙星敏感率为 93.0 3%。结论 :托百士是高效的抗感染药 ,治疗外眼感染 (尤其是绿脓杆菌感染 )可作为首选 Objective: To evaluate the clinical efficacy of Topsil (0.3% Tobramycin) ophthalmic drugs. Methods: Patients with external eye infection were randomly divided into two groups. The control group was treated with ofloxacin and the control group was treated with or without fluoxetine 4 to 5 days and 9 to 10 days respectively. According to clinical observation (symptom and Signs comprehensive score) and bacterial culture to determine the results of drug treatment. Results: In 115 patients with bacterial culture positive external eye infection, there were 75 cases in Topsil group, 36 cases were markedly effective, 34 cases were effective, 70 cases were effective and 93.33% effective; 40 cases were ofloxacin group, 15 cases were markedly effective, Effective in 21 cases, the total effective 36 cases, the efficiency of 90%; no significant difference between the two statistics. Susceptibility test tobramycin sensitivity was 93.97%, ofloxacin sensitivity was 93.0 3%. CONCLUSIONS: Topaz is a highly effective anti-infective and can be used as first choice for the treatment of external eye infections (especially Pseudomonas aeruginosa infections)