目的 :观测地氟醚用于临床吸入麻醉时的药代动力学特征。方法 :30例ASAⅠ～Ⅱ级行胸部手术病人应用地氟醚吸入全麻。术前用药为苯巴比妥钠 0 1 g、阿托品 0 5mg。静脉诱导气管插管后吸入地氟醚 ,根据临床需要调整吸入浓度。持续泵注维库溴铵维持肌松。手术结束前 30分钟停地氟醚 ,同时泵入小剂量异丙酚以过渡拔管。记录地氟醚吸入浓度 (FI)、肺泡浓度 (FA)、输入浓度 (FD)及停止吸入时的肺泡浓度 (FAO)。观察FI∶FD=1 / 2及FA∶FD=1 / 2的时间。结果 :地氟醚的FI∶FD=1 / 2及FA∶FD=1 / 2的时间分别是 0 63分钟和 2 88分钟 ,停吸入后 ,平均 2 46分钟FA 达FAO的 50 %。结论 :地氟醚的低血 /气分配系数使其在体内的吸收和排出迅速 ,麻醉深浅易调可控。FA 接近FD 的速度快 ,提示在低流量麻醉中应用地氟醚更可取 Objective: To observe the pharmacokinetics of desflurane for clinical inhalation anesthesia. Methods: Thirty patients with ASA Ⅰ ~ Ⅱ thoracic surgery underwent general anesthesia with desflurane inhalation. Preoperative medication phenobarbital 0 1 g, atropine 0 5mg. Intravenous induction of tracheal intubation desflurane, inhalation concentration adjusted according to clinical needs. Vecuronium pump continued to maintain muscle relaxants. 30 minutes before the end of surgery to desflurane, while pumping small doses of propofol to extubation. The concentration of desflurane inhalation (FI), alveolar concentration (FA), input concentration (FD) and alveolar concentration at stopping inhalation (FAO) were recorded. Observe the time of FI: FD = 1/2 and FA: FD = 1/2. RESULTS: Desflurane’s FI: FD = 1/2 and FA: FD = 1/2 were 0 63 min and 2 88 min, respectively, with an average FA of 466 min after inhalation of 50% of FAO. CONCLUSIONS: Desflurane’s low blood / gas partition coefficient makes it rapidly absorbed and excreted in the body and its anesthetic depth is easy to control. FA approaching FD is fast, suggesting that desflurane may be preferable in low-flow anesthesia