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目的 观察氟脲嘧啶 (5 Fu)持续静脉滴注不同时间联合醛氢叶酸 (LV)和奥沙利铂 (L OHP)治疗晚期大肠癌的疗效及毒性反应。方法 经病理组织学诊断的晚期大肠癌 39例。A组 :2 0例 ,L OHP 130mg/m2 静脉滴注 2h ,第 1d ;LV 2 0 0mg/m2 ,静脉滴注 2h ,随后 5 Fu 375mg/m2 静脉推注 10min ,再接 5 Fu3 0 /m2 用输液泵连续滴注 4 8h ,2 1d为 1个周期。B组 :19例 ,方案剂量同A组 ,其中 5 Fu 3 0 /m2 用输液泵连续滴注 12 0h ,2 1d为 1个周期。两组病例至少接受 2个周期治疗。结果 可评价的 35例中 ,A组 18例 ,B组 17例。A、B两组有效率分别为 38 9%、4 2 1% ,经统计学处理 ,差异无显著意义 (P >0 0 5 )。A组毒性大于B组。结论 L OHP +5 Fu +LV方案延长 5 Fu持续滴注时间未能提高疗效 ,却减轻了毒性反应。
Objective To observe the curative effect and toxicity of continuous infusion of 5-fluorouracil (5 Fu) for advanced colorectal cancer treated with different concentrations of alduronic acid (LV) and oxaliplatin (L OHP). Methods The histopathological diagnosis of advanced colorectal cancer in 39 cases. A group: 20 cases, L OHP 130mg / m2 intravenous infusion 2h, 1d; LV 200mg / m2, intravenous infusion 2h, then 5 Fu 375mg / m2 intravenous injection 10min, followed by 5 Fu3 0 / m2 With infusion pump continuous infusion 48h, 21d for a period. Group B: 19 cases, the same dose as Group A, of which 5 Fu 3 0 / m2 with infusion pump continuous infusion 12h, 21d for a cycle. Two groups of patients received at least 2 cycles of treatment. Results Among 35 evaluable cases, 18 cases were in group A and 17 cases were in group B. The effective rates of group A and group B were 38.9% and 42.1% respectively. There was no significant difference between the two groups (P> 0.05). A group of toxicity than B group. Conclusions LOHP +5 Fu + LV regimen prolongs the duration of 5 Fu infusion and fails to improve the curative effect, but reduces the toxic reaction.