论文部分内容阅读
结直肠癌(colorectal cancer,CRC)是结肠和直肠粘膜上皮在环境或遗传等致癌因素作用下发生的恶性病变。高脂、高能量、低纤维膳食、久坐不动的生活方式及肥胖等都是CRC的危险因素。Sporamin蛋白是甘薯块根中特有的一种胰蛋白酶抑制剂,具有抑制脂肪细胞分化和降低CRC细胞血管内皮生长因子和基质金属蛋白酶表达的作用。近年来,胰岛素样生长因子(insulin-like growth factors,IGFs)家族信号分子在肥胖及CRC发展过程中的作用引起了人们的重视。肥胖可导致IGF结合蛋白基因甲基化,并引起IGF1、IGF2等促癌因子分泌增多。反之,限制热量、减肥和增加体力活动则能逆转IGFs通路信号分子的不利改变,产生抑癌作用。本文分析了甘薯sporamin蛋白抑制CRC的可能机制,并将重点放在IGFs通路信号分子所起的作用上,为进一步阐明sporamin蛋白抗CRC的作用机制提出了新的研究方向。
Colorectal cancer (CRC) is a malignant disease of the colon and rectal mucosal epithelium that occurs under environmental or genetic carcinogenic factors. High-fat, high-energy, low-fiber diet, sedentary lifestyles and obesity are all risk factors for CRC. Sporamin is a trypsin inhibitor unique to sweet potato tuberous roots and has the effect of inhibiting adipocyte differentiation and decreasing the expression of vascular endothelial growth factor and matrix metalloproteinase in CRC cells. In recent years, the role of insulin-like growth factors (IGFs) family signaling molecules in the development of obesity and CRC has aroused people’s attention. Obesity can lead to IGF binding protein gene methylation, and cause IGF1, IGF2 and other pro-cancer factors increased secretion. Conversely, limiting calories, losing weight and increasing physical activity can reverse the unfavorable changes of signaling molecules of IGFs pathway and produce tumor suppressor effect. In this paper, we analyzed the possible mechanism of sporamin inhibition of sweet potato, and focused on the role of IGF signaling pathway signaling molecules, which provided a new research direction for elucidating the mechanism of sporamin protein anti-CRC effect.