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目的观察2型糖尿病患者无症状性颅内动脉狭窄的经颅多普勒(TCD)特点及其危险因素。方法收集135例体检2型糖尿病患者,排除合并中风、高血压及其他颅内疾病。用TCD检查颅内动脉狭窄情况,观察年龄和血尿酸水平对颅内动脉狭窄的影响。结果135例患者中有39例有颅内动脉狭窄,患病率为28.89%。检查动脉1 115条,狭窄动脉57条,总的动脉狭窄率为5.11%。其中大脑中动脉(MCA)狭窄率最高,大脑后动脉未出现狭窄。颈内动脉系统的动脉狭窄率显著高于椎基底动脉系统。老年组患者总的颅内动脉狭窄率及单一动脉狭窄率均高于非老年组患者。狭窄组血尿酸水平明显高于非狭窄组。结论2型糖尿病患者颅内动脉狭窄最常发生于大脑中动脉,年龄和血尿酸水平升高是2型糖尿病患者无症状性颅内动脉狭窄的危险因素。
Objective To observe the characteristics and risk factors of transcranial Doppler (TCD) of asymptomatic intracranial arterial stenosis in type 2 diabetic patients. Methods A total of 135 cases of type 2 diabetic patients were collected to exclude stroke, hypertension and other intracranial diseases. TCD examination of intracranial artery stenosis, observation of age and serum uric acid level on the impact of intracranial artery stenosis. Results Of the 135 patients, 39 had intracranial artery stenosis with a prevalence of 28.89%. 1 115 arteries and 57 stenotic arteries were examined. The total stenosis rate was 5.11%. Including the middle cerebral artery (MCA) stenosis rate is highest, there is no stenosis in the posterior cerebral artery. The rate of stenosis of the internal carotid artery was significantly higher than that of the vertebrobasilar artery. The total intracranial stenosis rate and single artery stenosis rate in the elderly group were higher than those in the non-elderly group. Serum uric acid levels were significantly higher in the stenosis group than in the non-stenosis group. Conclusions Intracranial artery stenosis occurs most frequently in the middle cerebral artery of patients with type 2 diabetes mellitus, and age and serum uric acid levels are risk factors of asymptomatic intracranial arterial stenosis in type 2 diabetic patients.