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磷霉素是一种抗生素,有很广的抗菌谱,在动物和人体中能预防氨基甙类所引起的肾毒和耳毒作用。本文研究旨在通过动物实验来研究磷霉素对顺铂引起耳毒反应的保护作用。作者通过对4组大鼠在1～10天内分别静脉注入顺铂1,2,5,10mg kg日,总量为10mg/kg。有的大鼠给以磷霉素300mg/kg,以资比较。结果:给顺铂10mg/kg日的大鼠多数死于实验之中;其它三组均有体重减轻、内耳中毒及肾毒反应,而同时给顺铂和磷霉素的比单纯给顺铂的反应为轻。内耳中毒表现为外毛细胞缺失,而内毛细胞均完好无损。外毛细胞缺失以基底转内圈第一排
Fosfomycin is an antibiotic with a broad antimicrobial spectrum that prevents nephrotoxic and ototoxic effects caused by aminoglycosides in both animals and humans. This study aims to study the protective effect of fosfomycin on cisplatin-induced ototoxicity by animal experiments. The authors intravenous cisplatin 1, 2, 5, 10 mg kg daily intravenously in 4 groups of rats within 1 ~ 10 days for a total of 10 mg / kg. Some rats given fosfomycin 300mg / kg, to compare. Results: Most of the rats on cisplatin 10 mg / kg day died from the experiment. The other three groups all had weight loss, poisoning of the inner ear and nephrotoxicity, while cisplatin and fosfomycin than cisplatin The reaction is light. Inner ear poisoning showed the absence of outer hair cells, while the inner hair cells were intact. Outer hair cells missing the first turn to the inner circle of the base