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[Objective] to screen the anti-inflammatory fraction from HERBA COMMELINAE.[Methods] Anti-inflammatory fraction was screened by using mice auricle swelling model induced by xylene,mice abdominal capillary permeability model induced by glacial acetic acid,rats pedal swelling model induced by carrageenan,and effects on PGE2 in inflammatory tissue of rats pedal edema induced by carrageenan.[Results]Compared with 5% Tween-80 group,the high-and middle dosage groups(30,15 g/kg) of water fraction had significantly inhibitory effects on mice auricle swelling induced by xylene,mice abdominal capillary permeability induced by glacial acetic acid,rats pedal swelling induced by carrageenan,and PGE2 in inflammatory tissue of rats pedal edema induced by carrageenan(P<0.05,0.01).Other fractions had weak or basically no activities.[Conclusions] Water fraction was the anti-inflammatory active fraction of HERBA COMMELINAE.
[Objective] to screen the anti-inflammatory fraction from HERBA COMMELINAE. [Methods] Anti-inflammatory fraction was screened by using mice auricle swelling model induced by xylene, mice abdominal capillary permeability model induced by glacial acetic acid, rats pedal swelling model induced by carrageenan, and effects on PGE2 in inflammatory tissue of rats pedal edema induced by carrageenan. [Results] Compared with 5% Tween-80 group, the high-and middle dosage groups (30,15 g / kg) of water fraction had significant inhibitory effects on mice auricle swelling induced by xylene, mice abdominal capillary permeability induced by glacial acetic acid, rats pedal swelling induced by carrageenan, and PGE2 in inflammatory tissue of rats pedal edema induced by carrageenan (P <0.05, 0.01) .Other fractions had weak or basically no activities. [Conclusions] Water fraction was the anti-inflammatory active fraction of HERBA COMMELINAE.