为探索食管和贲门早癌激光治疗的五年生存率和影响其预后的因素，对内镜Ｎｄ：ＹＡＧ激光治疗后癌细胞消失的３２例食管和贲门早期浅表癌病人进行了３３－７８个月（平均５５．３个月）的前瞻性随访。应用Ｐｒｏｄｕｃｔ ｌｉｍｉｔ ｅｓｔｉｍａｔｅ方法计算其存活率；并与１１７例食管和贲门早期浅表癌的自然病程进行了对比分析。内镜激光治疗五年存活率为９７％，未经治疗的早期食管贲门癌五年存活率为６７％，（Ｐ＜０．０１），表明内镜Ｎｄ：ＹＡＧ激光是一种有效的治疗方法。在对影响疗效因素的分析中，发现癌基因ｐ５３是一个有价值的独立预后因素。 In order to explore the five-year survival rate of the esophageal and cardial adnexal cancer laser treatment and the factors affecting its prognosis, 33-78 patients with early esophageal and cardiac cancer were treated with endoscopic Nd:YAG laser treatment. Months (average 55.3 months) of prospective follow-up. The product limit estimate method was used to calculate the survival rate; and the natural course of 117 esophageal and cardia early superficial carcinomas were compared and analyzed. The five-year survival rate of endoscopic laser therapy was 97%, and the five-year survival rate of untreated early esophageal and cardia cancer was 67% (P<0.01), indicating that endoscopic Nd:YAG laser is an effective treatment method. . In the analysis of factors affecting efficacy, the oncogene p53 was found to be a valuable independent prognostic factor.