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目的 观察生长抑素制剂 (施他宁、善得定 )对于肝硬化食道胃底静脉曲张破裂出血的治疗效果 ,并与垂体后叶素进行比较。方法 6 4例患者随机分为垂体后叶素组 (n =2 1)、施他宁组 (n =2 0 )、善得定组 (n =2 3)进行治疗。结果 垂体后叶素组、施他宁组和善得定组患者自接诊后至完全止血时的出血量 ,及接诊后至止血后 4 8小时生命体征基本平稳时的输血量无显著性差异 (P >0 0 5)。各治疗组 2 4小时内的止血率均为 80 %左右 (P >0 0 5)。结论 我们认为生长抑素作为肝硬化食道胃底静脉破裂出血治疗方法的一种选择 ,疗效肯定 ,但近期治疗效果并不明显优于垂体后叶素。
Objective To observe the therapeutic effect of somatostatin (Stratarin and Tramadol) on the treatment of patients with esophageal variceal bleeding due to cirrhosis and compare with that of pituitrin. Methods Sixty-four patients were randomly divided into three groups: the pituitrin group (n = 21), the shitamine group (n = 20) and the shaddidin group (n = 23). Results There was no significant difference in the amount of blood transfusion between the group of pituitrin, the group of patients receiving strychnine and the group of good-to-treat, the number of blood transfusions from the time of diagnosis to complete hemostasis, and the stable vital signs at 48 hours after admission (P> 0 0 5). The hemostasis rate within 24 hours in each treatment group was about 80% (P> 0.05). Conclusions We think that somatostatin is an effective treatment for patients with cirrhosis and esophageal variceal hemorrhage. However, the effect of treatment is not significantly better than that of pituitrin.