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目的 探讨急性脑血管病中医辨证分型与血浆胃动素的关系。方法 将350例急性脑血管病患者辨证分为痰热腑实、风痰火亢、风痰瘀阻、风火上扰、痰湿蒙神、气虚血瘀、阴虚风动型7个证型,每个证型各50例,另设健康对照组50例,观察组与对照组均在入院后翌日、排便后翌日、病程第7天和第14天清晨空腹平卧采肘静脉血测定血浆胃动素。最后运用华西医科大学卫生统计学教研室提供的Pems软件包进行统计学处理。结果 急性脑血管病患者血浆MTL水平显著高于正常人。其中以痰热腑实型、风痰瘀阻型、痰湿蒙神型、气虚血瘀型的空腹血浆胃动素水平较正常对照组显著升高,差异有非常显著性(P<0.01)。其中急性出血性脑血管病(ICH)的其余各证型差异亦有非常显著性(P<0.01),急性缺血性脑血管病(CI)的风火上扰、阴虚风动型差异有显著性(P<0.05)。结论 急性脑血管病中医辨证分型与血浆胃动素浓度有相关性。为临床辨病与辨证相结合,指导临床合理应用通腑药提供了一个客观指标。
Objective To investigate the relationship between TCM syndrome differentiation and plasma motilin in acute cerebrovascular disease. Methods 350 cases of patients with acute cerebrovascular disease were divided into phlegm and heat organs, wind phlegm, phlegm stasis, Wind and fire on the disturbance, phlegm Mongolian, qi deficiency and blood stasis, yin deficiency type seven card types , 50 cases for each syndrome, and another 50 cases of healthy control group. The observation group and the control group were on the following day after admission, the day after defecation, on the 7th day and the 14th day in the morning, Motilin. Finally, the Pems software package provided by the Department of Health Statistics of Huaxi Medical University was used for statistical analysis. Results The level of plasma MTL in patients with acute cerebrovascular disease was significantly higher than that in normal people. Among them, the levels of fasting plasma motilin, such as phlegm and phlegm stasis type, Phlegm wet Mongolian type and qi deficiency and blood stasis type, were significantly higher than those in normal control group (P <0.01). There were also significant differences in the other syndrome types of acute hemorrhagic cerebrovascular disease (ICH) (P <0.01), the differences of wind-induced disturbance and yin-deficiency of acute ischemic cerebrovascular disease Significance (P <0.05). Conclusion There is a correlation between TCM syndrome differentiation and plasma motilin in acute cerebrovascular disease. Clinical disease differentiation and syndrome differentiation combined to guide the clinical application of Tongfu medicine reasonable to provide an objective indicator.