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曾有报道利多卡因(简称Lid)治疗对苯巴比妥及安定反差的重症新生儿惊厥可能有效。现研究的目的是评价不同胎龄的新生儿治疗期间Lid血浓度、其主要代谢产物和抗惊厥效果之间的关系。同时评价在监测治疗中检测Lid的血浓度是否有意义。病人和方法24例新生儿静脉注射Lid抗惊厥过程中,Lid及其代谢产物—乙酯酰替二甲苯胺甘氨酸(MEGX)和酰替二甲苯胺甘氨酸(GX)的血浓度,这些新生儿应用Lid前均已接受苯巴比妥或安定治疗。惊厥
It has been reported that lidocaine (referred to as Lid) treatment of phenobarbital and diazepam in severe neonatal convulsions may be effective. The purpose of this study was to evaluate the relationship between Lid blood concentration, its major metabolites, and anticonvulsant effect during neonatal treatment of different gestational age. At the same time, it was evaluated whether it is meaningful to monitor the blood concentration of Lid during the monitoring treatment. Patients and Methods In 24 neonates with intravenous Lid anticonvulsant, the concentrations of Lid and its metabolites, MEGX and GX, were used in these neonates Before Lid have received phenobarbital or diazepam treatment. Convulsions