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目的:分析在糖尿病肾病的早期治疗中应用卡托普利的临床疗效,探讨其作用机理。方法:针对89例早期糖尿病肾病病例进行早期药物治疗,随机抽取50例作为卡托普利组的观察对象,服用卡托普利,其余39例作为贝那普利组的参照对象,服用贝那普利药物,评价两组疗效,对比45天后血糖、蛋白尿等检测指标的变化。结果:卡托普利组有效率为92.0%,贝那普利组有效率为61.5%,卡托普利组与贝那普利组对比存在差异性(P<0.05)。卡托普利组各检测指标的数值显著降低,与用药前对比存在差异性(P<0.05);贝那普利组各检测指标的数值略有降低,与用药前对比存在差异性(P<0.05),与卡托普利组对比存在差异性(P<0.05)。结论:在糖尿病肾病的早期治疗中应用卡托普利能够获得显著疗效,使相关的指标检测数值出现恢复性改变。
Objective: To analyze the clinical efficacy of captopril in the early treatment of diabetic nephropathy and to explore the mechanism of action. Methods: A total of 89 patients with early diabetic nephropathy were treated with early medication. Fifty patients were selected randomly as captopril group and captopril as control group. The remaining 39 patients were enrolled as benazepril group, Puli drugs, evaluation of two groups of curative effect, compared with 45 days after the blood glucose, proteinuria and other indicators of detection changes. Results: The effective rate of captopril group was 92.0%, the effective rate of benazepril group was 61.5%, there was significant difference between captopril group and benazepril group (P <0.05). The values of each index of captopril group were significantly lower than those before treatment (P <0.05). The values of each index of benazepril group were slightly lower than those before treatment (P < 0.05), there was significant difference compared with captopril group (P <0.05). Conclusion: The application of captopril in the early treatment of diabetic nephropathy can obtain a significant effect, so that the value of the relevant indicators of detection of restorative changes.