论文部分内容阅读
[目的]探讨对宫颈细胞ASC-US进行HPV-DNA检测的分层筛查的临床价值。[方法]对2007年5月至2010年1月宫颈细胞学描述为ASC-US,经HPV-DNA检测、阴道镜检查和宫颈组织病理诊断,随访半年以上的资料相对完整的486例病例进行分析。[结果]ASC-US病例中306例为宫颈的一般性感染和湿疣样病变,占62.96%;180例为宫颈上皮内瘤变(CINⅠ～Ⅲ),占37.04%。486例ASC-US中HPV阳性300例。HPV阳性组300例中宫颈上皮内瘤变(CIN)156例,占61.73%,HPV阴性组186例中CIN24例,占12.9%,两组比较有显著性差异(P<0.01)。经过6～9个月的追踪观察,HPV阳性组再发CIN4例,HPV阴性组未出现新CIN病例。[结论]ASC-US与下生殖道HPV感染有关,HPV感染的ASC-US病例有较高的风险伴有CIN。ASC-US病例可根据HPV-DNA检测结果选择临床治疗及处理方法。
[Objective] To investigate the clinical value of cervical cancer ASC-US for stratified screening of HPV-DNA. [Methods] Cervical cytology described as ASC-US between May 2007 and January 2010 was analyzed in 486 cases with relatively complete data of more than six months follow-up by HPV-DNA test, colposcopy and cervical histopathology. . [Results] Among the ASC-US cases, 306 cases were common cervical lesions and condylomata-like lesions, accounting for 62.96%; 180 cases were cervical intraepithelial neoplasia (CINⅠ-Ⅲ), accounting for 37.04%. There were 300 HPV positive cases in 486 ASC-US patients. In HPV-positive group, 156 cases of cervical intraepithelial neoplasia (CIN) were found in 156 cases, accounting for 61.73%. Of HPV-negative group, 186 cases were CIN, accounting for 12.9%. There were significant differences between the two groups (P <0.01). After 6 to 9 months of follow-up observation, HPV positive group recurred CIN 4 cases, HPV negative group did not appear new CIN cases. [Conclusion] ASC-US is associated with lower genital HPV infection, and HPV-infected ASC-US cases have a higher risk of CIN. ASC-US cases based on HPV-DNA test results to choose the clinical treatment and treatment.