成人型呼吸窘迫综合征(ARDS)发病机制复杂,缺乏有效治疗,晚期死亡率高达60％～70％。尽管20余年来国内外学者对平原ARDS进行了深入的研究,但对发生在高原的ARDS(高原ARDS)研究仅偶见病例报道。本研究早期应用川芎嗪防治模拟4000米高原下犬RDS,观察其疗效并探讨作用机制。 1 材料与方法 犬同种脂肪液制备采用乙醚提取法。减压舱模拟海拔4000米高原气压,上升速度3米/秒。成年犬 Adult respiratory distress syndrome (ARDS) pathogenesis is complex, the lack of effective treatment, the late mortality rate as high as 60% to 70%. Although more than 20 years of domestic and foreign scholars conducted an in-depth study of ARDS in the plains, only occasional cases were reported on the ARDS (plateau ARDS) study on the plateau. In this study, tetramethylpyrazine (TMP) was used to prevent and treat RDS in dogs at a height of 4 000 m, and its therapeutic effect was observed and its mechanism of action was explored. 1 Materials and Methods Canine fat liquid preparation using ether extraction method. Decompression chamber altitude 4,000 meters above sea level plateau pressure, the rising speed of 3 m / s. Adult dog