观察了ｔＰＡ对体外培养的牛晶体上皮细胞的增殖、胶原和透明质酸合成的影响。结果表明ｔＰＡ对细胞增殖和胶原合成无影响；可使细胞透明质酸合成减少，以８０００ｕ／ｍｌ时效果较明显。提示（１）其抑制后囊混浊形成作用是通过减少纤维蛋白和其对晶体上皮细胞的作用来实现；（２）其用于眼部是安全的。 The effects of tPA on the proliferation, collagen and hyaluronic acid synthesis of cultured bovine lens epithelial cells were observed. The results show that tPA has no effect on cell proliferation and collagen synthesis; can reduce the synthesis of hyaluronic acid cells, 8000u / ml when the effect is more obvious. It is suggested that (1) its inhibition of posterior capsule opacification is achieved by reducing fibrin and its effect on the lens epithelial cells; (2) it is safe for the eye.