【摘 要】
：
Metabolism study has been carried out on l-hydroxy-2,3,5-trimethoxyxanthone (HM-1) and l-hydroxy-2,3,4,7-tetramethoxyxanthone (HM-2), which are two biologically
【机 构】
：
Institute of Materia Medico,Department of Ophthalmology,School of Chinese Medicine,Department of Pha
论文部分内容阅读
Metabolism study has been carried out on l-hydroxy-2,3,5-trimethoxyxanthone (HM-1) and l-hydroxy-2,3,4,7-tetramethoxyxanthone (HM-2), which are two biologically active ingredients isolated from the Tibetan herb, Halenia elliptica D. Don., in rat liver microsomes in vitro. A method of high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry (LCMSn-ESI-IT-TOF) was applied to analyze metabolites of HM-1 and HM-2 on line, and five metabolites were identified containing l,5-dihydroxy-2,3-dimethoxyxanthone (HM-5), l,7-dihydroxy-2,3,4-trimethoxyxanthone (HM-9), 1,4, 7-trihydroxy-2,3-dimethoxyxanthone (HM-10), l,4-dihydroxy-2,3,7-trimethoxyxanthone (HM-11) and l,2-dihydroxy-3,4,7-trimethoxyxanthone (HM-12). Among these metabolites, HM-9, HM-11, and HM-12 were isomers mutually. The results indicated that HM-1 and HM-2 occurred Phase I metabolic reaction of demethylation in rat microsomes in vitro.
其他文献
目的探索开展中学生HIV/AIDS健康教育干预模式的效果。方法在深圳宝安区随机抽取8所中学学校,随机分为干预组和对照组(各4所),对干预组进行每月一次(共持续4个月)的HIV/AIDS
Facile synthesis of the two new natural heterocyclic compounds bretschneiderazines A (2) and B (3), isolated from an extract of the stems of Bretschneidera sine
A mild, efficient and high yielding protocol for the synthesis of 2,2'-arylmethelene dicyclohexane-1,3-dione derivatives at room temperature and 9-aryl-l,8-dihy
Melamine and poly vinylpyrrolidone (PVP) reacted with neat sulfuric acid readily to form two new organic solid acids namely melamine-(H2SO4)3 and PVP-(H2SO4)n.
Antimony (Sb) has received increasing environmental concerns due to its potential toxic and carcinogenic properties.In the present work,the electrocoagulation t
Various 2-phenylimidazo [4,5-f] [1,10] phenanthrolines were synthesized from potassium ferro-cyanide trihydrate (KFCT) complex catalyzed three component reactio
Synergistic removal of aniline by carbon nanotubes and the enzymes of Delftia sp.XYJ6,a newly isolated bacterial strain for biodegrading aniline,was investigate
To further expand an effective modified route for the shift from an antibacterial fluoroquinolone (FQ) to an antitumor FQ, two series of title compounds based o
Silica gel-supported polyphosphoric acid (PPA-SiO2) was found to be an efficient catalyst for the one-pot four-component Hantzsch condensation reaction of aryl
The inclusion complex of β-cyclodextrin (β-CD) with 4-chlorobenzoic acid was synthesized and its crystal structure was determined by single crystal X-ray diff