已知细胞因子在幽门螺杆菌(Hp)相关胃、十二指肠疾病中起着重要的作用,但诱导产生细胞因子的确切机制尚不清楚。脲酶是从Hp细胞中提取的一种主要的蛋白成分,据认为是Hp感染导致胃粘膜炎症的毒力因子。然而,至今尚未有人用人胃上皮细胞研究其对脲酶刺激的反应。 Cytokines are known to play an important role in Helicobacter pylori (Hp) -related gastric and duodenal diseases, but the exact mechanism by which cytokines are produced is not known. Urease, a major protein component extracted from Hp cells, is thought to be a virulence factor for Hp infection leading to gastric mucosal inflammation. However, so far no human gastric epithelial cells have been used to study their response to urease stimulation.