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目的通过对肝细胞性肝癌(hepatocellular carcinoma,HCC)住院病例的调查,探讨广西贵港地区乙型肝炎病毒(简称乙肝)感染及HCC家族史与HCC患者住院年龄的关系。方法应用临床流行病学横断面的研究方法,以2004～2008年贵港市人民医院首次住院的HCC患者1365例为研究对象。回顾性构建调查表的数据库,对贵港地区乙肝感染及HCC家族史与HCC患者住院年龄进行相关性分析。结果 HCC家族史(+)者住院年龄较HCC家族史(-)者小(P<0.05);HCC病例中乙肝(-)者住院年龄与乙肝(+)者的差异无统计学意义(P=0.738);以乙肝(-)且HCC家族史(-)者作为参照组,乙肝(+)且HCC家族史(-)组与之比较,患者住院年龄的差异无统计学意义(P=0.443),乙肝(-)且HCC家族史(+)者及乙肝(+)且HCC家族史(+)者的住院年龄均偏小(P均<0.05)。结论①无论是否有乙肝感染,HCC家族史(+)的肝癌患者住院年龄均较HCC家族史(-)者小;②HCC家族史及乙肝感染史与贵港地区HCC患者的住院年龄有关系。
Objective To investigate the relationship between hepatitis B virus (HCC) infection, family history of HCC and hospitalization age in HCC patients in Guigang area of Guangxi by investigation of inpatients with hepatocellular carcinoma (HCC). Methods Using the clinical epidemiological cross-sectional study, 1365 HCC patients who were hospitalized for the first time in Guigang People’s Hospital from 2004 to 2008 were selected as research objects. The database of retrospectively constructed questionnaire was used to analyze the correlation between hepatitis B infection, family history of HCC and hospitalization age of patients with HCC in Guigang area. Results The length of hospitalization of HCC family members (+) was smaller than that of HCC family members (-) (P <0.05). There was no significant difference in the age of hospitalization between hepatitis B patients and those with hepatitis B patients (P = 0.738). There was no significant difference in age of hospitalization among patients with hepatitis B (+) and HCC family history (-) with hepatitis B (-) and family history of HCC as reference group (P = 0.443) , The age of hospitalization of hepatitis B (-), HCC family history (+) and hepatitis B (+) and HCC family history (+) were all smaller (all P <0.05). Conclusion ① The hospitalization ages of patients with HCC with family history of HCC (+) are less than those with family history of HCC (with or without HCC) with or without HBV infection. (2) The family history of HCC and the history of hepatitis B infection are related to the hospitalization age of patients with HCC in Guigang area.