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细胞色素P450(cytochrome p450,P450s)是一类数量众多、功能复杂的血红素结合蛋白,对许多内源、外源化合物起着氧化代谢作用。线虫作为地球上生存策略最多样的动物之一,对其细胞色素P450基因研究很少,仅对模式线虫秀丽隐杆线虫等少数几种线虫P450s有部分研究。过去一直认为寄生线虫中氧化代谢不是其主要的代谢过程,然而越来越多的研究表明P450s在寄生线虫中也发挥重要作用。本文通过与秀丽隐杆线虫基因组中P450s相比较,综述已开展研究的几种寄生线虫:马来丝虫(Brugia malayi),旋盘尾丝虫(Onchocerca volvulus)和捻转血茅线虫(Haemonchus contortus)基因组中P450s的数量、种类、功能和进化研究,为其他线虫特别是寄生线虫的生长发育和抗药性研究提供理论依据和研究模式。
Cytochrome P450 (P450s) is a large number of complex heme-binding proteins that play a role in oxidative metabolism to many endogenous and exogenous compounds. As one of the most survival animals on earth, nematode has little research on its cytochrome P450 gene, and only some studies on a few nematodes such as C. elegans P450s. In the past, it has been thought that oxidative metabolism in parasitic nematodes is not its main metabolic process, however, more and more studies have shown that P450s also play an important role in parasitic nematodes. In this paper, we review several parasitic nematodes that have been studied by comparison with P450s in C. elegans genome: Brugia malayi, Onchocerca volvulus and Haemonchus contortus ) Genome of P450s in the number, type, function and evolution of other nematodes, especially parasitic nematodes, growth and development and resistance studies provide a theoretical basis and research model.