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来那度胺(Lenalidomide,CC-5013,商品名Revlimid)是美国Cel-gene公司开发生产的第2代免疫调节药物,为沙利度胺(thalidomide,反应停)的4-氨基-戊二酞基衍生物,这一化学结构改变使其化学性质比沙利度胺更稳定且具有更强的抑制血管生成和免疫调节作用,而且神经毒性和致畸性减少。2
Lenalidomide (CC-5013, trade name Revlimid) is a second-generation immunomodulatory drug developed and produced by Cel-gene Company in the United States. It is thalidomide (reaction stop) Based derivatives, this chemical structure change makes it chemically more stable than thalidomide and has a stronger inhibition of angiogenesis and immunomodulatory effects, and reduced neurotoxicity and teratogenicity. 2