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目的探讨和分析激素替代疗法对绝经后女性内分泌及脂代谢情况的影响。方法 150例绝经后女性,随机分为观察组和对照组,各75例。对照组不给予治疗,观察组给予激素替代疗法治疗。观察两组代谢水平以及性激素水平。结果观察组在治疗后血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及三酰甘油(TG)与治疗前比较差异无统计学意义(P>0.05),对照组TG、TC以及LDL-C显著高于治疗前,HDL-C低于治疗前,差异有统计学意义(P<0.05);经过半年治疗后,观察组血清雌二醇(E2)、尿促卵泡素(FSH)和黄体生成素(LH)与治疗前相比,差异无统计学意义(P>0.05),但对照组LH、FSH显著高于治疗前,E2低于治疗前,差异有统计学意义(P<0.05)。结论激素替代疗法对绝经后女性内分泌具有改善作用,且能够显著改善患者脂代谢情况。
Objective To investigate and analyze the effect of hormone replacement therapy on endocrine and lipid metabolism in postmenopausal women. Methods 150 cases of postmenopausal women, were randomly divided into observation group and control group, 75 cases each. The control group did not receive treatment, the observation group was given hormone replacement therapy. The metabolic and sex hormone levels were observed in both groups. Results There was no significant difference in serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) (P> 0.05). The levels of TG, TC and LDL-C in the control group were significantly higher than those before treatment and before HDL-C treatment, the difference was statistically significant (P <0.05); after six months of treatment, E2, FSH and LH were not significantly different from those before treatment (P> 0.05), but the levels of LH and FSH in the control group were significantly higher than those before treatment and E2 were lower than those before treatment Before the difference was statistically significant (P <0.05). Conclusion Hormone replacement therapy can improve endocrine in postmenopausal women, and can significantly improve the lipid metabolism in patients.