Ebola virus outbreak in Africa in 2014 is a big global issue.The vaccine is the hope for management of the present outbreak of Ebola virus infection.There are several ongoing researches on new Ebola vaccine.In this short manuscript,we discuss and put forward specific remained problems to be answered on this specific issue.Lack for complete knowledge on the new emerging virus,concern from pharmaceutical company and good trial of new vaccine candidates are the remained problem to be further discussed in vaccinology. Ebola virus outbreak in Africa in 2014 is a big global issue. Vaccine is the hope for management of the present outbreak of Ebola virus infection. There are several ongoing researches on new Ebola vaccine. In this short manuscript, we discuss and put forward specific remaining problems to be answered on this specific issue. Lack for complete knowledge on the new emerging virus, concern from pharmaceutical company and good trial of new vaccine candidates are the remained problem to be further discussed in vaccinology.