临床研究证实,在创面愈合及瘢痕形成过程中,很多细胞介质参与调节成纤维细胞的生物学活动,如增殖、合成胶原、收缩功能变化等[1,2]。其中转化生长因子β1是正性作用的生长因子,而干扰素(IFN-γ)是具有负性作用的细胞因子[3,4]。体外实验证实,肿瘤坏死因子(TNF-α)和IFN-γ... Clinical studies have confirmed that in the process of wound healing and scar formation, many cell mediators are involved in the regulation of the biological activities of fibroblasts, such as proliferation, collagen synthesis, changes in systolic function [1,2]. Transforming growth factor β1 is a positive growth factor, and interferon (IFN-γ) is a negative cytokine [3,4]. In vitro experiments confirmed that tumor necrosis factor (TNF-α) and IFN-γ