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目的观察奥沙利铂联合氟脲嘧啶、亚叶酸钙治疗晚期大肠癌的近期疗效和不良反应。方法20例晚期大肠癌患者采用奥沙利铂+5-FU/CF全身化疗,观察其近期疗效和不良反应。结果共治疗20例,疗效:部分缓解(PR)9例,无变化(NC)4例,恶化(PD)7例,总有效率45%。不良反应主要为可逆性周围神经毒性、胃肠道反应及贫血、白细胞减少。结论本方案治疗晚期大肠癌疗效确切,不良反应轻,是治疗晚期大肠癌的理想方案。
Objective To observe the short-term curative effect and adverse reaction of oxaliplatin combined with fluorouracil and leucovorin in the treatment of advanced colorectal cancer. Methods Twenty patients with advanced colorectal cancer were treated with oxaliplatin + 5-FU / CF systemic chemotherapy. The curative effect and adverse reactions were observed. Results A total of 20 cases were treated. There were 9 cases of partial remission (PR), 4 cases of no change (NC) and 7 cases of worsening (PD). The total effective rate was 45%. Adverse reactions are mainly reversible peripheral neurotoxicity, gastrointestinal reactions and anemia, leukopenia. Conclusion The treatment of advanced colorectal cancer with definite effect and light adverse reactions is an ideal treatment for advanced colorectal cancer.