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［目的］ 进一步了解接触平均浓度为１．０７ｍ ｇ／ｍ ３ 丙酮氰醇（Ａｃｅｔｏｎｅ Ｃｙａｎｏｈｙｄｒｉｎ，ＡＣ）的职业人群健康状况调查。［方法］ 通过职业性健康体检及尿硫氰酸盐（ＳＣＮ）等指标的实验室检查对４６ 名ＡＣ作业人员组和４６名不接触毒害因素人员组进行配对研究。［结果］ ①ＡＣ作业人群可有类神经症表现，且头昏、记忆力减退、食欲减退、恶心、腹胀痛等植物神经功能紊乱症状出现率较对照组高（Ｐ＜ ０．０５），但无阳性体征发现。②血清γ－ＧＴ、ＢＵＮ比对照组明显增高（Ｐ＜ ０．０５），而ＡＬＴ、ＡＬＰ、ＣＲＥ及尿ＳＣＮ 等未见明显改变。接触ＡＣ人群外周血淋巴细胞微核率与对照组相比，无明显升高，但是吸烟与ＡＣ遗传效应之间可能存在某种协同作用。［结论］ ＡＣ在目前浓度对接触人群的健康仍会发生一定影响，应重视对ＡＣ作业人群的健康监护。
[Objective] To investigate the occupational health status of Acetone Cyanohydrin (AC) with an average contact concentration of 1.07 m g / m 3. [Methods] The 46 AC workers group and 46 non-contact toxicant group were mated through the laboratory examination of occupational health examination and SCN index. [Results] (1) The subjects with AC were able to show neurosis, dizziness, memory loss, loss of appetite, nausea, abdominal pain and other symptoms of autonomic dysfunction than the control group (P <0.05), but no positive Signs found. ② Serum levels of γ-GT and BUN were significantly higher than those of the control group (P <0.05), while ALT, ALP, CRE and urinary SCN showed no significant changes. Compared with the control group, the micronucleus rate of peripheral blood lymphocytes in AC exposure group was not significantly increased, but there may be some synergy between smoking and AC genetic effect. [Conclusion] There is still some effect of AC in the current concentration on the health of the exposed population, and the health monitoring of the AC working population should be emphasized.