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再生障碍性贫血(简称再障)是一个综合征,因其发病机理复杂,不能完全以某一种特殊病因来解释。近年来关于这方面的研究有相当大的进展。现将其分为两个部分作一简述:①再障的发病机理;②再障的现代治疗。再障的发病机理免疫的机理 1970年Mathe′等先用抗淋巴细胞血清预备再障患者,然后移植组织不相容的骨髓,结果造血功能恢复,没有出现移植物抗宿主病(GVHD)。在这以后,人们研究免疫与再障之间的关系有较多的了解。
Aplastic anemia (referred to as aplastic anemia) is a syndrome, because of its complex pathogenesis, can not be completely explained by a particular cause. In recent years, considerable progress has been made in this aspect of research. Now it is divided into two parts for a brief description: ① the pathogenesis of aplastic anemia; ② aplastic anemia of the modern treatment. Pathogenesis of aplastic anemia Immune mechanism In 1970, Mathe et al first prepared patients with aplastic anemia with anti-lymphocyte serum and then transplanted incompatible tissue marrow. As a result, hematopoietic function recovered and graft-versus-host disease (GVHD) did not occur. Since then, people have a better understanding of the relationship between immunity and aplastic anemia.