一种新的生长激素给药系统——诺狄自用注射器

来源 :国外医学.药学分册 | 被引量 : 0次 | 上传用户:jsdkhfahdjfk
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
人体生长激素(hGH)作为儿童生长激素缺乏症(GHD)的补充治疗药已愈30多年。直至最近几年治疗儿童GHD的方法仍用注射器和药瓶,每周肌注2~3次。最近研究表明,用同等剂量的重组人体生长激素(r—hGH)每天皮下注射可明显增加生长速率。为便于重复使用,著者研究了r-hGH给药装置诺狄(nordiject 24)笔式注射器。该注射器长145 mm,重35g,针头为27号(0.4×12.5mm),内含2mlr—hGH(12IU/mlnorditropin),针头长度用不同轴环进行调节,可调范围为10,8,6mm,以0.9%苄醇为冰冻干燥的r-hGH再生溶剂。剂量由套筒沟槽的刻度进行调节,一种刻度可预先设置 Human growth hormone (hGH) has been used as a supplementary therapeutic drug for childhood growth hormone deficiency (GHD) for more than 30 years. Until recent years, the treatment of children with GHD still use syringes and bottles, intramuscular injection of 2 to 3 times a week. Recent studies have shown that daily subcutaneous injections of the same dose of recombinant human growth hormone (r-hGH) can significantly increase the growth rate. For ease of reuse, the authors studied the nordiject 24 pen injector r-hGH drug delivery device. The syringe is 145 mm long and weighs 35 g with a 27 gauge needle (0.4 × 12.5 mm) containing 2 ml r-hGH (12 IU / ml norditropin). The needle length is adjusted with different collars and the adjustable range is 10, 8, 6 mm , R-hGH regeneration solvent with 0.9% benzyl alcohol as freeze-dried. The dose is adjusted by the scale of the sleeve groove, and a scale can be preset
其他文献