新近提出的动脉扩张假说认为,外周动脉扩张引起机体有效循环血量下降是肝硬化钠水潴留、腹水形成的始动因素。内源性阿片肽(EOP)是一种强有力的血管扩张因子,肝硬化时由于肝脏灭活功能减弱,血中此肽浓度升高,在钠水潴留、腹水形成中起重要作用。本文重点回顾了肝硬化时EOP的变化及其作用,试图为肝硬化钠水潴留、腹水形成机理增加新内容。 The newly proposed arterial dilation hypothesis that the expansion of peripheral arteries caused by the effective blood circulation is decreased cirrhosis of the liver water retention, ascites formation of the initiating factor. Endogenous opioid peptide (EOP) is a potent vasodilator, which is attenuated by liver inactivation during liver cirrhosis and increased in serum concentration of this peptide, playing an important role in sodium and water retention and ascites formation. This article reviews the changes and the role of EOP during cirrhosis, and attempts to add new content to the mechanism of sodium and water retention in cirrhosis and the formation of ascites.