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目的:对六味地黄丸缺味药进行Bayes 法和PRIMA法定性识别研究。方法:采用反相HPLC法对六味地黄丸缺味药模拟方的浸出物进行分析,选取9 个色谱峰的峰面积与内标峰面积之比值作为样本特征变量,通过169 个训练集样本建立了其中3 种缺味药的Bayes 法和PRIMA法判别分析数学模型。结果:3 种缺味药4 种模式的平均正确识别率Bayes 法和PRIMA 法均为100% ,对169 个预示集样本的平均预示率Bayes 法为100% ,PRIMA法为99 .6% 。结论:Bayes 法和PRIMA 法能对六味地黄丸3 种缺味药进行准确识别。
OBJECTIVE: To study the Bayesian and PRIMA statutory identification of Liuweidihuang Pills. METHODS: Reversed-phase HPLC method was used to analyze the extracts from the simulated side of Liuweidihuang Pills. The ratio of the peak area of the 9 peaks to the peak area of the internal standard was selected as the sample feature variable. The sample was established with 169 training sets. Among them, Bayesian and PRIMA discriminant analysis mathematical models of 3 kinds of odor-reducing drugs. Results: The average correct recognition rates of the four modes of the three kinds of odor-absorption drugs were 100% for the Bayesian and PRIMA methods. The average predictive rate for the 169 predictive samples was 100% for the Bayes method and 99 for the PRIMA method. 6%. Conclusion: The Bayes method and PRIMA method can accurately identify the three kinds of odor-reducing drugs in Liuwei Dihuang Wan.