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目的探究重度子痫前期孕妇甲状腺功能变化及其与重度子痫前期发病的关系。方法选取127例于2015年1月-2015年12月来我院治疗的重度子痫前期孕妇为观察组,按发病孕周分为早发型86例,晚发型41例。选取同时期来我院检查的127例健康孕妇为对照组。利用化学发光微粒免疫分析技术检测孕妇血清中促甲状腺激素、游离三碘甲状腺原氨酸及游离甲状腺素水平,化学发光法测定孕妇甲状腺过氧化物酶抗体、甲状腺球蛋白抗体水平。对比分析两组孕妇的甲状腺功能。结果观察组孕妇促甲状腺激水平、甲状腺过氧化物酶抗体阳性率、甲状腺球蛋白抗体阳性率、甲减及亚甲减发生率明显高于对照组(P<0.05),观察组游离三碘甲状腺原氨酸及游离甲状腺素水平明显低于对照组(P<0.05),两组孕妇甲亢及亚甲亢发生率差异比较无统计学意义(P>0.05)。结论与正常孕妇相比,重度子痫前期孕妇促甲状腺激素较高,游离三碘甲状腺原氨酸及游离甲状腺素水平较低,且甲亢及亚甲亢发生率明显升高,重度子痫前期发病与甲状腺功能异常密切相关。
Objective To investigate the thyroid function in pregnant women with severe preeclampsia and its relationship with severe preeclampsia. Methods A total of 127 pregnant women with severe preeclampsia who were treated in our hospital from January 2015 to December 2015 were selected as the observation group. According to the gestational age, 86 cases were early-onset and 41 were late-onset. Select the same period to our hospital for examination of 127 healthy pregnant women as control group. Chemiluminescent microparticle immunoassay was used to detect serum thyrotropin, free triiodothyronine and free thyroxine in pregnant women, and chemiluminescence method was used to detect thyroid peroxidase and thyroglobulin antibody levels in pregnant women. Comparative analysis of the two groups of pregnant women’s thyroid function. Results The level of thyroid stimulating hormone, the positive rate of thyroid peroxidase antibody, the positive rate of thyroglobulin antibody, the incidence of hypothyroidism and hypothyroidism in the observation group were significantly higher than those in the control group (P <0.05). The free triiodothyroidism (P <0.05). There was no significant difference in the incidence of hyperthyroidism and hyperthyroidism between the two groups (P> 0.05). Conclusion Compared with normal pregnant women, pregnant women with severe preeclampsia have higher levels of thyrotropin, free triiodothyronine and free thyroxine, and the incidence of hyperthyroidism and hyperthyroidism is significantly increased. The incidence of severe preeclampsia and Thyroid dysfunction is closely related.