Objective:To explore the effectiveness of Danhong Injection (丹红注射液) on improvin microcirculatory injury after percutaneous coronary intervention (PCI) in patients with coronary heart disease(CHD).Methods:A randomized controlled trial was conducted and 90 patients were enrolled.A random sequence was generated using statistical analysis software.Patients with microcirculatory injuries after PCI were randomly divided into 3 groups for treatment (30 subjects in each group):Danhong Injection group:after PCI,Danghong Injections were given with intravenous administration with 40 mL twice a day for a week;statins intensive group:after PCI,atorvastatin calcium tablets were given oral medication with 80 mg once,and then atorvastatin 40 mg daily for 1 week;the control group:after PCI,atorvastatin calcium tablets were given oral medication with 10-20 mg daily for 1 week.The index of microcirculation resistance (IMR) was used to assess microcirculatory injury during PCI.The IMR of the target vessel was reexamined after 1 week of drug treatment.Results:After one week\'s drug treatment,IMR was significantly decreased in both statins intensive group and Danhong Injection group compared with the control group (P＜0.01),but no difference was found between statins intensive group and Danhong injection group (14.03 + 2.54 vs.16.03 + 5.72 U,P=0.080).Conclusions:The efficacy of Danhong Injection is non-inferior to statin.Early use of Danhong Injection after PCI can effectively improve coronary microcirculation injury after PCI.