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目的观察颐年降压饮治疗早期高血压病患者临床疗效及其在血管内皮细胞功能方面的作用机制。方法选取早期原发性高血压中医证属痰瘀阻络、肝阳偏亢型患者79例,随机分为治疗组40例与对照组39例,分别给予颐年降压饮和天麻钩藤饮进行治疗,观察治疗前后两组中医证候积分和血压的变化,治疗后测定患者血清一氧化氮(NO)、内皮素(ET)的含量。结果治疗组中医证候积分、降压疗效与对照组比较有统计学差异(P<0.05),治疗后两组患者血清ET、NO含量比较亦有统计学差异(P<0.05)。结论颐年降压饮具有改善早期原发性高血压患者中医证候、降低血压等疗效,可能与其调节ET、NO失衡,进而恢复血管内皮依赖性舒张功能有关。
Objective To observe the clinical efficacy of Yienian Jiangyin Decoction in the treatment of early-stage hypertensive patients and its mechanism of action in vascular endothelial cells. Methods 79 patients with early primary hypertension were identified as phlegm-blood stasis syndrome and liver yang hyperactivity type. They were randomly divided into treatment group (40 cases) and control group (39 cases) The changes of TCM syndrome scores and blood pressure were observed before and after treatment. The levels of serum nitric oxide (NO) and endothelin (ET) were measured after treatment. Results The scores of TCM syndromes and antihypertensive efficacy in the treatment group were significantly different from those in the control group (P <0.05). The levels of ET and NO in the two groups were also significantly different after treatment (P <0.05). Conclusion Yi nian Jiangya Decoction can improve TCM symptoms and reduce blood pressure in patients with early-stage essential hypertension, which may be related to the regulation of ET and NO imbalance and the restoration of endothelium-dependent vasodilation.