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目的探讨食管鳞癌组织CD44v6与E-钙黏蛋白(E-cad)表达与其临床病理特征的关系。方法采用免疫组化法检测48例食管鳞癌(A组)、23例糜烂性食管炎(B组)和24例正常食管黏膜组织(C组)CD44v6和E-cad的表达,分析其表达与食管鳞癌临床病理特征的关系。结果 A组CD44v6表达明显高于B、C组,而E-cad表达明显低于B、C组(P<0.05)。CD44v6和E-cad的表达与食管鳞癌浸润深度和淋巴结转移密切相关(P<0.05)。食管鳞癌组织中CD44v6和E-cad表达水平呈负相关(r=-0.580,P<0.05)。结论联合检测病变组织中CD44v6与E-cad的表达有望成为食管鳞癌筛查及预后判断的辅助指标。
Objective To investigate the relationship between CD44v6, E-cadherin and clinicopathological features in esophageal squamous cell carcinoma. Methods The expressions of CD44v6 and E-cad in 48 cases of esophageal squamous cell carcinoma (A group), 23 cases of erosive esophagitis (Group B) and 24 cases of normal esophageal mucosa (Group C) were detected by immunohistochemistry Relationship between clinicopathological features and esophageal squamous cell. Results The expression of CD44v6 in group A was significantly higher than those in group B and C, while the expression of E-cad was significantly lower in group A than in group B and C (P <0.05). The expressions of CD44v6 and E-cad were closely related to the invasion depth and lymph node metastasis of ESCC (P <0.05). The expression of CD44v6 and E-cad in esophageal squamous cell carcinoma was negatively correlated (r = -0.580, P <0.05). Conclusions The combined detection of CD44v6 and E-cad in lesion tissues is expected to be an auxiliary index for screening and prognosis of esophageal squamous cell carcinoma.