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家兔45只喂以高脂饮食,以形成实验性动脉粥样硬化,对其中7只家兔的主动脉标本,包括主动脉正常部位、肋间动脉开口及斑块部进行扫描电镜观察,并以3只正常饮食的家兔作对照。 观察结果,在正常与高脂饮食家兔的主动脉内膜面均有灶性分布的虫蛀状内皮损害,在肋间动脉口附近更为多见。可以设想,这种病损可以增加动脉内膜的通透性,促进血浆脂质渗入动脉壁,因此,它们对粥样斑块的形成可能具有重要意义。
Forty-five rabbits were fed a high-fat diet to induce experimental atherosclerosis. Scanning electron microscopy was performed on aorta specimens of seven rabbits, including normal aorta, intercostal artery openings, and plaque Three rabbits with normal diet were used as controls. Observations, in the normal and high-fat diet rabbit aortic intima have focal distribution of worm-like endothelial damage, more common in the vicinity of the intercostal artery. It is conceivable that this lesion may increase the permeability of the arterial intima and promote the penetration of plasma lipids into the arterial wall, and thus they may have important implications for the formation of atherosclerotic plaques.