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目的 探讨咳喘灵贴膏治疗慢性支气管炎的临床疗效及作用机制。方法 设立治疗、对照两组 ,治疗组(5 9例 )在背部胸椎 1～ 6两侧 (定喘、大杼、风门、肺俞、心俞 )用咳喘灵贴膏 (由麻黄、杏仁、半厦、地龙、白芥子组成 )贴敷 ,对照组 (2 5例 )用斯奇康注射液肌肉注射 ,两组均连续用药 2 0次 ,用药前后记录患者临床症状 ,拍胸部X线片 ,测定免疫球蛋白 (IgG、IgA及IgM)和T细胞亚群 (CD3、CD4 及CD8)水平 ,并随访 0 .5、1年。结果 治疗组临床总有效率达 93 .2 % ,胸部X线片改善总有效率为 40 .7% ;对照组分别为 80 .0 %和 2 0 .0 %。停药后 0 .5、1年的临床总有效率 ,治疗组分别为 91.5 %、89.8% ,对照组分别为 80 .0 %、76.0 %。总有效率治疗组均明显优于对照组 (P <0 .0 5 )。IgG和CD8的变化治疗组均优于对照组 (P <0 .0 5 )。结论 咳喘灵贴膏能调节免疫功能 ,是一种疗效高、远期疗效好的透皮吸收剂。
Objective To investigate the clinical efficacy and mechanism of Kechuanling plaster in the treatment of chronic bronchitis. Methods The treatment group was established. The treatment group (59 cases) was treated with Kechuanling plaster (ephedra, almonds, almonds, Half ground, earthworm, mustard seed paste), the control group (25 cases) were injected intramuscularly with Stichikkam injection, both groups were administered 20 times continuously before and after treatment, the patient’s clinical symptoms were recorded, chest X-ray film The levels of immunoglobulin (IgG, IgA and IgM) and T lymphocyte subsets (CD3, CD4 and CD8) were measured and followed up for 0.5 years and 1 year. Results The total effective rate of the treatment group was 93.2%, the total effective rate of the chest X-ray film was 40.7%, and the control group was 80.0% and 20.0% respectively. The total clinical effective rate at 0. 5 and 1 year after drug withdrawal was 91.5% and 89.8% respectively in the treatment group and 80.0% and 76.0% in the control group respectively. The total effective rate in the treatment group was significantly better than that in the control group (P <0.05). The changes of IgG and CD8 in the treatment group were better than those in the control group (P <0.05). Conclusion Kechuanling paste can regulate immune function, is a high efficacy, long-term efficacy of transdermal absorbers.