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目的评价热碘油栓塞对兔VX2肝癌的抑瘤效果。方法将VX2瘤细胞接种于30只新西兰白兔肝左叶,建立兔肝癌模型,随机分为A、B和C3组,每组10只。利用导管经肝动脉分别给生理盐水(A组)、37°C碘油(B组)和60°C碘油(C组),7d后观察各组肿瘤体积及血清AST水平,观察瘤兔的存活期。结果C组肿瘤的生长率(0.92±0.21)与A组(3.48±1.17)和B组(1.29±0.26)相比有差异(P<0.05)。C组的存活期(41.0±3.0)d与A组(31.5±3.0)d相比有差异(P<0.05)。C组血清AST水平与B组相比无差异(P>0.05),与A组相比有差异(P<0.05)。结论60°C碘油栓塞兔VX2肝癌可明显降低肿瘤生长率并延长存活期。
Objective To evaluate the anti-tumor effect of thermal oil embolization on VX2 liver cancer in rabbits. Methods VX2 tumor cells were inoculated into the left lobe of 30 New Zealand white rabbits to establish a model of rabbit liver cancer and were randomly divided into A, B and C3 groups, with 10 in each group. (A group), lipiodol group (B group) and 60 ° C lipiodol group (C group) via hepatic artery respectively. After 7 days, the tumor volume and AST level in each group were observed. Survival. Results The growth rate of tumor in group C (0.92 ± 0.21) was significantly lower than that in group A (3.48 ± 1.17) and group B (1.29 ± 0.26) (P <0.05). The survival time of group C (41.0 ± 3.0) d was significantly different from that of group A (31.5 ± 3.0) d (P <0.05). There was no significant difference in serum AST between group C and group B (P> 0.05), but there was difference between group C and group A (P <0.05). Conclusion 60 ° C lipiodol embolism rabbit VX2 liver cancer can significantly reduce tumor growth rate and prolong survival.